
⸺ Synova Research
Mitochondria-targeted tetrapeptide (elamipretide) studied for mitochondrial membrane stabilisation, ATP production and oxidative-stress protection in preclinical models.
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⸺ Important
⸺ Overview
SS-31 (also known as elamipretide or Bendavia) is a cell-permeable tetrapeptide that selectively targets the inner mitochondrial membrane. Researchers study it for its interaction with cardiolipin and its role in supporting mitochondrial structure, energy production and protection against oxidative damage.
⸺ Mechanism of Action
SS-31 binds selectively to cardiolipin in the inner mitochondrial membrane, stabilising cristae architecture and improving electron transport chain efficiency. In animal models this reduces reactive oxygen species generation and supports ATP synthesis under stress conditions.
⸺ Research
Preclinical studies report improved mitochondrial respiration and ATP output in aged and stressed tissue models.
Animal research describes reduced ROS production and lipid peroxidation following SS-31 administration.
Research has explored SS-31 in models of heart failure and skeletal-muscle dysfunction, with improved functional outcomes.
Summarised from preclinical literature for informational purposes only. Not medical or veterinary advice. Synova Research products are sold strictly for in-vitro and laboratory research.
⸺ Details

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