
⸺ Synova Research
Modified GHRH analogue (also known as Mod GRF 1-29) studied in preclinical models for pulsatile growth hormone release.
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⸺ Important
⸺ Overview
CJC-1295 without DAC is a synthetic growth hormone releasing hormone (GHRH) analogue with a short half-life. Researchers use it in animal models to study short, pulse-like growth hormone signalling, often alongside secretagogues such as Ipamorelin.
⸺ Mechanism of Action
It binds GHRH receptors on the pituitary, prompting a brief burst of growth hormone release. Without the drug affinity complex (DAC), it clears quickly, producing a pulse that more closely mimics natural secretion patterns in rodent studies.
⸺ Research
Animal work reports short-lived rises in growth hormone and IGF-1 following administration, used to model natural secretion rhythms.
Preclinical studies pair GHRH analogues with ghrelin-receptor secretagogues to examine additive pituitary responses.
Researchers examine downstream IGF-1 signalling in connective tissue and muscle repair models.
Summarised from preclinical literature for informational purposes only. Not medical or veterinary advice. Synova Research products are sold strictly for in-vitro and laboratory research.
⸺ Details

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Synthetic analogue of the GLP-1 hormone used in research to study glucose regulation, insulin secretion and the incretin response.